...
Registration number: ПИ №ФС77-235В7,
8th March 2008. ISSN: 1815-445X
8th March 2008. ISSN: 1815-445X
Correction of the investigatory and exploratory deficiency in rat with multipotent mesenchymal stromal cells
HTML
PDF1. The Trans-Technologies Ltd., Saint Petersburg
2. The Research Institute of Experimental Medicine, the North-Western Branch of RAMS, Saint Petersburg
2. The Research Institute of Experimental Medicine, the North-Western Branch of RAMS, Saint Petersburg
Keywords:
multipotential mesenchymal stromal cells, a brain trauma, cellular therapy, behaviour
multipotential mesenchymal stromal cells, a brain trauma, cellular therapy, behaviour
The possibility of locomotory and exploratory behavior correction after minimal
sensorimotor cortex trauma was studied in a rat model. Testing in «open field»
showed that the behavior of rats from the cell therapy group recovered to
normal [values] by the 4th week after trauma, whereas no spontaneous increase
of locomotory and exploratory activities was observed in the control group.
Moreover, after MSC transplantation the quantity of microvessels and
morphologically intact neurons in the border zone of trauma was greater as
compared with the control. As a result, the damaged tissue volume was less in
the cell therapy group due to reduction of delayed neuronal loss. What is more,
MSC injection prevented degeneration of white matter tracts in the caudate
nucleus.
Unfortunetely, only registered users are allowed to leave comments.
1. Соколова И.Б., Федотова О.Р., Зинькова Н.Н. и др. Влияние трансплантации мезенхимальных стволовых клеток на когнитивные функции крыс после ишемического инсульта. Клеточные технологии в биологии и медицине 200В; 4: 202-5.
2. Mahmood A., Lu D., Wang L. et al. Treatment of traumatic brain injury in female rats with intravenous administration of bone marrow stromal cells. Neurosurg. 2001; 49: 1196-203.
3. Bhang S., Lee Y., Cho S-W. et al. Basic fibroblast growth factor promotes bone marrow stromal cell transplantation-mediated neural regeneration in traumatic brain injury. Biochem. Biophys. Res. Com. 2007; 359: 40-5.
4. Соколова И. В., Зинькова Н. Н., Билибина А. А. и др. Возможности применения клеточной терапии при лечении ишемического инсульта в эксперименте. Клеточная трансплантология и тканевая инженерия 2007; 2(4): 54-62.
5. Петров Е.С. Изучение нейробиологических основ сложных безусловных рефлексов в Физиологическом отделе им. И.П.Павлова: итоги последних лет. Рос. физиол. журн. им. И.М. Сеченова 1990; 84 [123: 1669-81.
6. Пошивалов В.П. Экспериментальная психофармакология агрессивного поведения. Л.: Наука, 1986.
7. Paxinos G., Watson Ch. The rat brain in stereotaxic coordinates. Mew York. Academic Press. 1998.
8. Mahmood A., Lu D., Wang L. et al. Treatment of traumatic brain injury in female rats with intravenous administration of bone marrow stromal cells. Neurosurg. 2001; 49(5): 1196-203.
9. Mahmood A., LuD., ChoppM. Marrow stromal cell transplantation after traumatic brain injury promotes cellular proliferation within the brain. Neurosurg. 2004; 55(5]; 1185-92.
10. Kang J., Kang K., Koo H. et al. Soluble factors-mediated immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells. Stem cells dev. 2008; 17: 681-94.
11. Du Y., Zhou S., Zhou T. et al. Immuno-inflammatory regulation effect of mesenchymal stem cell transplantation in rat model of myocardial infarction. Cytotherapy 2008; 10(5): 469-78.
12. Chen L., Tredget E., Wu P., Wu Y. Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PloS one 2008; 3(4): 1-12.
13. Arvidsson A., Collin Т., Kirik D. et al. Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat. Med. 2002; 9: 963-70.
14. Darsalia V., Heldmann U., Lindvall 0., Kakaia Z. Stroke-induced neurogenesis in aged brain. Stroke. 2005; 36(8): 1790-5.
15. Chen X., Li Y., Wang L. et al. Human bone marrow stromal cell cultures conditioned by traumatic brain tissue extracts: growth factor production. J. Neuroscience res. 2002; 69(5): 687-91.
16. Костюк П. Г. Физиология центральной нервной системы. М., МГУ, 1997.
17. Stoll G., Jander S., Schroeter M. Inflammation and glial responses in ischemic brain lesions. Prog. Neurobiol. 1998; 56(2): 149-71.