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Registration number: ПИ №ФС77-235В7,
8th March 2008. ISSN: 1815-445X
8th March 2008. ISSN: 1815-445X
Correction of the investigatory and exploratory deficiency in rat with multipotent mesenchymal stromal cells
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PDF1. Trans-Technologies Ltd., Saint Petersburg, Russia
2. Research Institute of Experimental Medicine, North-Western Branch of RAMS, Saint Petersburg, Russia
2. Research Institute of Experimental Medicine, North-Western Branch of RAMS, Saint Petersburg, Russia
Keywords:
multipotential mesenchymal stromal cells, a brain trauma, cellular therapy, behaviour
multipotential mesenchymal stromal cells, a brain trauma, cellular therapy, behaviour
The possibility of locomotory and exploratory behavior correction after minimal
sensorimotor cortex trauma was studied in a rat model. Testing in «open field»
showed that the behavior of rats from the cell therapy group recovered to
normal (values) by the 4th week after trauma, whereas no spontaneous increase of locomotory and exploratory activities was observed in the control group.
Moreover, after MSC transplantation the quantity of microvessels and
morphologically intact neurons in the border zone of trauma was greater as
compared with the control. As a result, the damaged tissue volume was less in
the cell therapy group due to reduction of delayed neuronal loss. What is more,
MSC injection prevented degeneration of white matter tracts in the caudate
nucleus.
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