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The effects of multipotent mesenchymal stem cells transplantation on post traumatic processes after the experimental traumatic brain injury

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PDF, Volume IV, №3, 2009

Grigorian A.S¹, Gilerovich E.G², Pavlichenko N.N¹, Kruglyakov P.V¹, Sokolova I.B¹, Polyntsev D.G¹

1. Trans-Technologies Ltd., Saint-Petersburg, Russia
2. Intitute for Experimental Medicine, RAMS, Saint-Petersburg, Russia

Keywords:
multipotent mesenchyaml stem cells, craniocerebral trauma, traumatic brain injury, basal ganglia, neurons

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The influence of different transplantation methods of multipotent mesenchymal stromal cells (MMSC) on post-traumatic processes after the experimental brain injury in rats was studied. It was shown, that inspite of the transplantation method the MMSC hasten inflammation and glial scar formation in the injury boudary zone, and also preserve the normal morphology of the brain basal ganglia. The intravenous MMSC transplantation decreases the extent of brain tissue damage in neocortex and subcortical structures. It was shown by the first time that the injection of MMSC suspension into the injury boudary zone leads to the formation of neoplasms consisting of collagen-secreting MMSC, and also to the development of abnormal sinusoid cappilaries in the brain tissue in long-term post-traumatic period.

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