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Registration number: ПИ №ФС77-235В7,
8th March 2008. ISSN: 1815-445X
8th March 2008. ISSN: 1815-445X
Cell self-renewal in intestinal epithelium under conditions of cell reactive alterations
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PDF1. Military Medical academy, Saint Petersburg
2. State Medical academy named after I.I. Mechnikov, Saint Petersburg
2. State Medical academy named after I.I. Mechnikov, Saint Petersburg
Keywords:
intestinal epithelium, proliferation, apoptosis, intestinal stem cell, Ki-67, Bcl2, p53, new bladder
intestinal epithelium, proliferation, apoptosis, intestinal stem cell, Ki-67, Bcl2, p53, new bladder
A histological study of biopsy specimens in=52) was carried out. The specimens
were obtained from the ileum mucous membrane which had contacted with urine in
new bladders for a long time. Immunohistochemistry included an assessment of
enterocyte expression of cell cycle markers — Ki-B7, Bcl2, p53. Epithelial
proliferation was determined to be activated as early as 4—5 months after
beginning to contact with urine. The process of alteration of proliferative
activity consists of three phases: 1) activation, the proliferation index is
70—86% [during the first year), 2) stabilization at the level of 70% during the
second year, and 3) recurrent increase up to 97% later on. There is a
hypothesis that similar alterations are due to direct influence of intestinal
epithelium on stem cells. The expression level of Bcl2, p53 remained low.
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