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Modeling of functional osteogenesis using biodegradable matrix and autogenic stromal cells of subcutaneous adipose tissue

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PDF, Volume IV, №1, 2009

V.S. Melikhova¹, I.N. Saburina¹, A.A. Orlov²,I.A. Martirosyan², V.S. Repin¹, N.I. Novikova³, A.N. Murashev³

1. Institute of General Pathology and Pathophysiology, Moscow
2. Clinical Hospital № 85, Dentistry Clinics Dental «Academy»
3. Institute of Bioorganic Chemistry (Branch] RAS, Moscow

Keywords:
stem cells, bone tissue engineering

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The study was aimed to prove the possibility to use a tissue engineered construction based on /33- calcium phosphate (ChronOs™J and stromal cells of subcutaneous adipose tissue to induce de novo osteogenesis after limited marginal resection of a mandible branch in Sprague Dawley rats. The technique of immobilization the given material with progenitor-cells capable not only to differentiate in the osteogenic way but also to provide the implant with nutrients via vessel formation was developed. The vessel number was revealed to increase within the cell-containing implant as well as accelerated formation of functioning osseous tissue as compared with the controls.

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