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Registration number: ПИ №ФС77-235В7,
8th March 2008. ISSN: 1815-445X



Stem cells in regenerative therapy of cardiac pathology. The role of intercellular interactions.
E.Yu. Plotnikov1, D.B. Zorov2, G.T. Sukhikh1
1. V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology of Rosmedtechnologies, Moscow
2. A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University
Keywords:
stem and progenitor cells, cardiomiocytes, tunneling nanotubes, myocardial infarction
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Regenerative cell therapy represents the most perspective innovative method in treatment of consequences of a heart attacks of a myocardium both other functional and structural changes of a heart tissue. Are most widely used as a material for cellular transplantation and myocardium regeneration embryonic and meshenchymal stem cells, and also some other types of stem and progenitor cells. The primary goal assigned to stem cells — to be differentiated to the functionally active cardiomyocytes and to be integrated Into a myocardium tissue of the recipient. Management of a differentiation of stem cells goes in a myocardium at the expense of influence of a microenvironment and the direct intercellular signaling when cell-to-cell crosstalk between the neighboring cells regulates a differentiation direction. Now experimental acknowledgement was received by three basic types of interaction of stem/progenitor cells with cardiomyocytes, to some extent associated with a transdifferentiation. These are cell fusion, formation of intercellular contacts of gap-junction and recently found interaction type — tunneling nanotubes (TNTsl. In the review we consider the data on positive effects of stem and progenitor cells in heart pathologies and a role of intercellular interactions in realization of these effects.

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